Giants WR Odell Beckham Jr. and CB Eli Apple were listed as limited participants in Thursday's practice, the team announced hours before departing for London.
Beckham hurt his hip during last week's win over the Ravens. However offensive coordinator Mike Sullivan said the team is very optimistic that Beckham will play this week.
Apple is still recovering from a groin injury suffered during the team's Week Five loss to the Packers. Defensive coordinator Steve Spagnuolo told reporters that the Giants are hoping to have their rookie cornerback on Sunday.
LS Zak DeOssie, LB Keenan Robinson, and CB Trevin Wade were also limited in Thursday's practice.
While the protective boot has been removed from his foot, S Darian Thompson is still not practicing.
S Nat Berhe and OT Marshall Newhouse also sat out practice on Thursday.