Giants LB Jonathan Casillas (neck), S Landon Collins (ankle), RB Paul Perkins (ribs), C Weston Richburg (concussion), WR Sterling Shepard (ankle), and DE Olivier Vernon (ankle) all missed practice on Thursday for a second consecutive day.
DE Romeo Okwara (knee) was a limited participant.
Shepard, who sparined his ankle against the Chargers last Sunday, said earlier this week he has "no idea" if he will be ready for the Giants' game against the Broncos on Sunday night. However, Shepard does feel the ankle healing.
"I'm doing a lot better," he said. "Feels a lot better than it did yesterday, so that's a good start."
Vernon, who missed last week's game, said his ankle is feeling better.
Earlier this week, the Giants placed Odell Beckham Jr. (ankle surgery), Dwayne Harris (foot), and Brandon Marshall (ankle) on season-ending IR.