Giants CB Eli Apple, DT Jay Bromley, RB Shaun Draughn, and S Duke Ihenacho left the team's game against the Jets on Saturday with injuries.
Apple suffered an ankle injury, Bromley has a left knee sprain, and Draughn is being evaluated for a concussion. Ihenacho left the game with a knee injury.
Apple was ruled out for the remainder of the game, while Bromley's return was listed as questionable. There were no further updates on Draughn's condition.
Apple had previously missed time earlier in the month with an ankle injury, while Draughn is coming off ankle surgery. Draughn only had one carry for a loss of four yards before leaving the game.