Here are some starts and sits for each squad:
Start 'Em: Hakeem Nicks
I don't care if the 49ers own the league's No. 2-ranked defense in terms of total yardage; If Nicks is able is suit up for this game, he has to be in your lineup.
The Niners own both a top-10 rush and pass defense, the latter is second only to the Cowboys. Through five contests, the yardage (969) is definitely below the league average.
However, they have surrendered five touchdowns, which, by comparison, is the same amount the Cardinals and Lions have allowed. You'd start Hakeem the Dream against those D's, right?
The Niners best two defensive performances have come in the last two weeks -- against the Jets and Bills. Aaron Rodgers gashed the secondary for 256 yards, so it is doable.
Sit 'Em: Ahmad Bradshaw
After my spiel about how defensive statistics don't matter so much in this one, let me warn you this is not a great match-up for Bradshaw.
San Francisco is allowing the fewest fantasy points to opposing running backs in the NFL. Only Adrian Peterson topped the century mark against them (104). The Packers, Lions, Jets and Bills -- albeit not the best running teams -- all rushed for fewer than 70 yards.
It feels lousy to let Bradshaw ride the pine in this one, especially coming off of a 200-yard outburst against Cleveland last week. But if you need a flex, Bradshaw managed 126 total yards against the Niners in the NFC Championship Game. You could do worse.
Start 'Em: Frank Gore
The Giants defense have been a lot of things -- suspect may be one of the more suitable adjectives.
Don't get me started on their pass rush, or lack thereof.
Another area they have struggled with -- at times -- is the run. In the season opener, we all remember DeMarco Murray dominating the ground with a 131-yard performance. And just a few weeks back, LeSean McCoy did the same to the tune of 143 yards.
Last week, the Giants held Trent Richardson in check, but keep in mind that's against a Browns offense which isn't exactly a juggernaut. Alex Smith can make plays through the air, allowing the passing game to set up the run, and vice versa.
The Giants are a middle-of-the-pack D v. the run, and San Fran will try to establish their ground attack. Gore has scored in four of the team's five games this season, and is a viable option again Sunday.