Big Blue (3-2) is coming off of a convincing defeat of the Cleveland Browns, while San Francisco (4-1) has allowed all of 3 points in their last two contests, both against New York teams.
The all-times serious between the Giants and 49ers is knotted at 18 wins a piece, though San Fran owns an 11-8 edge in games at Candlestick Park.
Here's how the two teams stack up:
San Francisco 49ers:
- Known for being a defensive team, it has been the 49ers' offense has been more than steady this year.
- The 49ers have scored on 49 percent of their possessions, second only to -- you know it -- the Giants, who score on 51 percent.
- The running game has been the offense's strength. 49ers backs average over 6 yards per carry, the highest average for the team since 1954 and in the league since the '08 Giants.
- When Alex Smith does not throw an interception, the Niners are 14-1. When the team scores more than 20 points, they are 14-1.
- When the team allows fewer than two sacks, they're 11-0. The Giants were unable to sack Cleveland quarterback Brandon Weeden last week.
- Defensively, the Niners have picked off opposing quarterbacks n each of the 12 home contests. Eli Manning has thrown 5 interceptions this season, though only one has come on the road.
- The Giants have allowed 5 sacks this season. When the 49ers sack the quarterback three or more times, they are 10-0.
- In 2011, Manning threw two picks at Candlestick Park in a November game, but none in the NFC Championship Game victory.
- Under head coach Jim Harbaugh, the 49ers are 9-1 at home, undefeated in the month of October and 14-2 when they hold a halftime lead. They are undefeated when their offense produces more yardage and 12-1 when they win the time of possession battle.
- The Giants and 49ers rank 2nd and 3rd, respectively, in points per game.
- The Giants and 49ers rank 2nd and 6th in terms of total offense, respectively.
- The Niners own the league's top defense, allowing 13.6 points per game. The Giants, in contrast, have surrendered more than 22 points per game, ranked 14th in the league.
- The Niners have sacked opposing QBs 9 times, the Giants 8. The Giants have 8 interceptions, ranked 3rd in the NFL.
- Both of these squads own a great turnover differential. San Fran is +5 and New York is +4.
Passing: Alex Smith (1,087) v. Eli Manning (1,579)
Rushing: Frank Gore (432) v. Ahmad Bradshaw (333)
Receiving: Michael Crabtree (27-311) v. Victor Cruz (37-438)
Interceptions: NaVorro Bowman (1) v. Michael Boley (3)
Sacks: Aldon Smith (4.5) v. Osi Umenyiora/Chase Blackburn (2)