With center Weston Richburg among seven Giants players inactive for Sunday's game against the Denver Broncos, New York adjusted its offensive line to feature Brett Jones at center, DJ Fluker at right guard, John Jerry at left guard and Justin Pugh at right tackle.
Richburg is out due to a concussion after missing practice on Wednesday and Thursday.
The Giants also ruled defensive end Olivier Vernon (ankle), wide receiver Sterling Shepard (ankle), linebacker Jonathan Casillas (neck), defensive end Romeo Okwara (ankle), running back Paul Perkins (ribs) and quarterback David Webb out.
Orleans Darkwa will start at running back, Keenan Robinson at linebacker and Kerry Wynn at defensive end.
Earlier this week, the Giants placed Odell Beckham Jr. (ankle surgery), Dwayne Harris (foot) and Brandon Marshall (ankle) on season-ending IR.