The Giants have placed OL D.J. Fluker (toe), CB Donte Deayon (forearm), and LBs Curtis Grant (knee) and Deontae Skinner (hamstring) on injured reserve.
Fluker played in nine games for the Giants this season after signing as a free agent in March.
While adding the above four players to IR, the Giants added LBs Jeremy Cash and Ray Ray Armstrong to the active roster.
Cash, who played in eight games for the Panthers last season, was released from the Jets' practice squad last week.
Armstrong was claimed off waivers.