The Giants have placed RB Shane Vereen and QB Ryan Nassib on season-ending injured reserved, the team announced Tuesday.
Both players will have season-ending surgery this week, head coach Ben McAdoo said.
DL/LB Ishaq Williams and RB George Winn have been promoted to the active roster.
Vereen returned Sunday against the Lions after missing time with a concussion but re-injured the triceps that kept him out for nine games earlier this season.
Nassib (elbow) was inactive during Sunday.'s game. With him out, Josh Johnson becomes Eli Manning's backup.