The Giants ruled offensive lineman Justin Pugh and linebacker B.J. Goodson out for Sunday's game against the Kansas City Chiefs due to back and ankle injuries, respectively.
New York also listed defensive tackle Damon Harrison (ankle) and linebacker Devon Kennard (quad) questionable, while linebacker Kelvin Sheppard is doubtful to play due to a groin injury.
Harrison, who did not practice on Wednesday, was a limited practice participant on Thursday and Friday. Kennard and Sheppard were also limited at practice.
Cornerback Eli Apple returned to practice on Friday after he missed Thursday's due to a personal reason.