Giants LBs B.J. Goodson (ankle), Devon Kennard (quad), and Keenan Robinson (quad) are all listed as out for Sunday's game against the 49ers in San Francisco.
All three players missed practice on Thursday and Friday.
CB Donte Deayon (ankle) is doubtful, while LB Jonathan Casillas (neck), LB Calvin Munson (quad), DE Olivier Vernon (ankle), and DE Kerry Wynn (knee) are questionable.
Jason Pierre-Paul missed practice on Thursday, but the team said it was not injury-related. He was not on Friday's injury report.
Vernon and OL Justin Pugh, who both missed last week's blowout loss to the Rams, practiced on Wednesday, Thursday, and Friday on a limited basis.