The Giants ruled linebacker B.J. Goodson and wide receiver Tavarres King out for Sunday's game against the Arizona Cardinals due to an ankle injury and a concussion, respectively.
Goodson, 24, has appeared in just two games since Oct. 22.
Interim head coach Steve Spagnuolo also listed safety Landon Collins (ankle), defensive end Jason Pierre-Paul (finger) and safety Nat Berhe (hamstring) as questionable.
"He got a little bit of work in today," Spagnuolo said of Collins, who left Sunday's loss to the Philadelphia Eagles midway through and missed practice Thursday. "He clearly wants to play in Arizona."
Pierre-Paul wore a club on his right hand at Friday's practice to protect his finger, which he said is broken, however he added he plans on playing Sunday.