The reality of it is Nicks' status was already shaky, given that head coach Tom Coughlin stated earlier in the week he did not believe the top wideout's knee was improving.
Barden's concussion is an even worse sign. He caught just two balls for 36 yards in Sunday's loss to Philadelphia, but had a career performance in Week 3 against Carolina.
Tom Coughlin said this during his press conference:
"He complained of a headache. He asked that he could be evaluated and they sent him for the evaluation yesterday. I think a lot of the symptoms were ok, but there was enough there for them to slow him down."
"It was one of those plays at the end of the game. He said that he got a blow to the back of the head."
If both Nicks and Barden are out Sunday against Cleveland, the workload is shifted onto Victor Cruz, Martellus Bennett and Domenik Hixon.
Bennett was forced to help in pass protection against the Eagles' wide-9 Sunday night, but still Manning targeted him in the red zone and even on deep balls. Cleveland has a much less lethal pass rush, so he'll be able to run more routes.
Hixon becomes the main benefactor, fantasy-wise. Hixon started Week 4 and led the way with 114 yards against a talented Eagles secondary, and will have no troubles replicating that performance against a Joe Haden-less secondary.
Coughlin hinted Nicks may not practice Thursday, too,
"I'm not sure (if the knee is swollen)…I think it's a little bit, but not so as to inhibit him when he walks. He looks pretty good walking."
We'll keep you posted on any updates.