The Giants ruled wide receiver Sterling Shepard out for Thursday's game against the Washington Redskins due to an illness.
Shepard, who did not play in Sunday's 12-9 win over the Kansas City Chiefs due to migraine headaches, missed practice Tuesday and Wednesday.
Offensive guard D.J. Fluker (toe), linebacker B.J. Goodson (ankle), offensive lineman Justin Pugh (back), linebacker Calvin Munson (quad), cornerback Eli Apple and quarterback David Webb are also inactive.
Linebacker Jonathan Casillas (neck), long snapper Zak DeOssie (trap), defensive tackle Damon Harrison (ankle/elbow), linebacker Kelvin Sheppard (groin) and defensive end Olivier Vernon (shoulder) are all active despite being listed as questionable earlier in the week.
New York will start Chad Wheeler at right tackle, Jon Halapio at right guard and Sheppard at middle linebacker.
Without Shepard, who has 38 catches for 475 yards and one touchdown this season, the Giants will likely look toward tight end Evan Engram and wide receivers Tavarres King, Roger Lewis Jr. and Travis Rudolph in the passing game. New York has also played without Odell Beckham Jr., Brandon Marshall and Dwayne Harris due to season-ending injuries they suffered in Week 5.
Apple is a healthy scratch for the second straight week, a team source told SNY.tv's Ralph Vacchiano. The second-year cornerback missed last Sunday's game to be with his mother, who had recently undergone brain surgery. Given the short week, and considering Apple missed most of practice last week, head coach Ben McAdoo opted to stick with a secondary that forced three Chiefs interceptions.