Geno Smith turned the ball over twice and threw for one touchdown, however the Giants were outgained 401-265 in Sunday's 24-17 loss to Derek Carr and the Oakland Raiders at Oakland Coliseum.
Smith, starting for Eli Manning, whose consecutive starts streak of 210 games was snapped, completed 21 of 34 passes for 212 yards, however he was sacked twice and lost two fumbles, including one at the Oakland 4-yard line with 36 seconds left before halftime.
New York totaled just 65 rushing yards on 24 attempts, while the Raiders, led by Marshawn Lynch's 101 yards, ran for 109 yards as a team.
Evan Engram recorded seven catches for 99 receiving yards, while Sterling Shepard had three catches for 56 yards. Carr threw for 287 yards and a touchdown for the Raiders, who are in a three-way tie for first place in the AFC West. Without Michael Crabtree (suspension) or Amari Cooper (concussion), Cordarrelle Patterson led the Raiders with 97 receiving yards.
The Giants cut a 17-7 deficit down to three when Smith threw a 10-yard touchdown to Engram with 5:16 remaining, but Oakland responded with a four-play, 68-yard drive that ended with Carr's nine-yard touchdown pass to Johnny Holton that made it 24-14.
The Raiders took a 7-0 lead on their first possession thanks to a 51-yard Lynch touchdown run. Later in the first, the Giants tied it on an Orleans Darkwa one-yard rush up the middle.
Oakland kicked a field goal with 3:37 remaining in the second quarter to retake the lead. The Giants then blocked a Marquette King punt with 45 seconds remaining in the half to set them up in the red zone, but Kahlil Mack sacked Smith and recovered the loose ball to end the threat.
DeAndre Washington had a nine-yard touchdown run early in the fourth quarter to make it 17-7.