Giants star running back Saquon Barkley left Sunday's game against the Buccaneers during the second quarter with a high ankle sprain, a source confirmed to SNY's Ralph Vacchiano.
The Giants will learn more abut Barkley's injury on Monday after the running back undergoes an MRI.
Barkley was tackled down on the left sideline and landed awkwardly, coming up and immediately hopping on one leg, keeping his other off the ground and was noticeably wincing in pain.
Barkley had to be helped to the locker room with his arms around two trainers, and was initially listed as questionable to return.
Barkley came back out in the middle of the third quarter using crutches and his right foot in a boot, downgrading his status to out for the remainder of the game. The Giants announced during the game that Barkley suffered an ankle injury and told reporters afterward that it was a sprain.
Up until the point of injury, Barkley had rushed for 10 yards on eight attempts and caught four passes for 27 yards.
Barkley, the No. 2 overall pick in the 2018 NFL draft and last season's Offensive Rookie of the Year, has one touchdown so far this season.