Giants WR Sterling Shepard and CB Eli Apple are among seven players who will miss Sunday's game against the Chiefs, the team announced.
OL Justin Pugh, LB BJ Goodson, QB Davis Webb, LB Kelvin Sheppard, and OT John Grego are also inactive for the Giants.
Shepard, who has suffered from migraines, was already not likely to play. The Giants were originally going to see how Shepard was during his pre-game routine, according to SNY's Ralph Vacchiano.
Shepard had a career day last week against San Francisco with 11 catches for 142 yards.
The Giants' will look to Tavarres King, Roger Lewis Jr., and Travis Rudolph to make up the production from the receivers. Without Shepard, the offense would likely feature a heavy dose of Evan Engram.
Pugh is battling a back injury, while Goodson has dealt with a lingering ankle injury. Sheppard has a groin injury.