In addition to missing the first four games of the regular season due to a suspension for taking a banned substance he said was for fertility, Giants WR Golden Tate is now in concussion protocol.
Tate was targeted twice and reeled in one catch during Friday night's game against the Bears, with head coach Pat Shurmur saying on Sunday that Tate suffered the injury at some point during the game.
The Giants' fifth game of the regular season -- the one Tate is eligible to return for -- is Oct. 6 against the Vikings.
In addition to Tate being out for the first four games, the status of top receiver Sterling Shepard (finger) has been in doubt a bit, but he shed his non-contact jersey on Sunday and appears to be on track for the opener.
Aside from Shepard, the other Giants receivers expected to be active for the season opener on Sept. 8 against the Cowboys are Cody Latimer, Bennie Fowler, and Russell Shepard.
The Giants will also likely rely heavily on Evan Engram in the passing game.
As far as Tate, he spoke at length last week about accepting his suspension while maintaining the substance he took was for an innocent reason.
"I just thought, after we looked at the facts in the situation, that the NFL would be understanding," he said. "But because it's a no-tolerance policy, they, I guess, upheld the suspension. I have no problem accepting the punishment. Ultimately, I'm responsible for what's put in my body. The tough thing I'm dealing with is I'm letting down a lot of people -- my family, the guys in the locker room, the organization that brought me here. That's what's been crushing me."
After trading Odell Beckham Jr. to the Browns during the offseason, the Giants signed the 31-year-old Tate to a four-year deal worth $37.5 million.
Due to Tate's suspension, though, the Giants could have an easier path to part ways with him after the first year of his deal if they so choose.