1. Peyton Manning
When facing the Colts, the #1 priority is always stopping Peyton Manning. Playing from behind most of the game, Peyton was in top form in week 1 against the Texans. The Colts abandoned the running game, and the Texans still couldn't slow down Manning. The Giants' secondary will have their hands full with the deepest receiving core in the game, but stopping Peyton starts with the defensive line. If their defensive line comes out flat, the Colts could have 21 points at halftime.
2. Dwight Freeney
Just as Peyton Manning is the Colts' identity on offense, Freeney is the face of the defense. As good a pass rusher as their is in the game, the Giants' banged up O-line will have their hands full trying to slow him down. The loss of Kevin Boss means that blocking TE Bear Pascoe will have to lend a big hand to the pass blocking. The Giants' offensive line gets a big test with Freeney, and how they fare against him could be the key to the Giants' ability to move the ball.
3. Dallas Clark
Peyton Manning loves going to Clark; he lead the team with 13 targets last week. If the Giants' corners are doing a good job on the Colts' wide receivers, Manning always has Clark as a safety net. That is why Kenny Phillips will be so important in this matchup. He looked great in week 1, and will need to continue to improve in this battle with one of the game's elite tight ends.