DE Olivier Vernon is among seven inactive players for Sunday's Giants' Week 5 game against the Chargers at MetLife Stadium.
Vernon, who is dealing with an ankle injury, was listed as questionable this week after he was unable to finish last week's game against the Buccaneers.
C Weston Richburg will miss the game with a concussion, while RB Paul Perkins is out with a rib injury. QB Davis Webb, TE Matt LaCosse, CB Michael Hunter, and DT Robert Thomas are also inactive.
DE Jason Pierre-Paul was listed as questionable this week but will play on Sunday, as will DE Avery Moss, and G John Jerry
RB Orleans Darkwa will start in Perkins' place, while Brett Jones will play center and Kerry Wynn will replace Vernon at defensive end.