Giants defensive end Olivier Vernon will miss his third straight game due to an ankle injury when New York faces the Seattle Seahawks on Sunday at 4:25 p.m. at MetLife Stadium.
The Giants ruled Vernon, center Weston Richburg, running back Paul Perkins and linebackers Jonathan Casillas and Calvin Munson out, while listing wide receiver Sterling Shepard as questionable as the Giants look to win their second straight game.
Vernon, who hasn't played since Oct. 1, was a limited participant in practice on Wednesday but missed practice on Thursday.
Richburg has been dealing with a concussion, Perkins an injury to his ribs, Casillas a neck injury and Munson a quad injury.
Shepard, who missed last Sunday's game against the Denver Broncos, was a limited participant in Thursday's practice as he looks to return from an ankle injury.