Eli Manning was not immediately in synch with receivers Hakeem Nicks and Steve Smith, both who missed the past few weeks due to injuries.
A pass from Manning intended for Nicks was picked off by former Giant Frank Walker. The Vikings could only manage a 21-yard FG by Ryan Longwell after a 10-play drive.
The Giants second drive was stalled after Kevin Boss dropped one pass and could not find the handle on another, which was thrown slightly behind him.
Minnesota QB Tavaris Jackson banged knees with RB Adrian Peterson while exchanging a handoff. Both players went down in pain. Both players left the game and were being attended to on the sidelines at quarters' end.
The quarter ended with the Giants driving into Vikings territory.