QB Davis Webb is inactive for the Giants on Sunday, making Eli Manning the only backup for starting QB Geno Smith.
Earlier in the week, McAdoo said he was not willing to answer whether he would have three quarterbacks available.
When asked about the possibility of having to play Manning in case any issues arise with Smith, McAdoo said "I haven't done it before, so it would be different. It wouldn't be awkward. It's part of the game."
LB Jonathan Casillas, OL Justin Pugh, CB Eli Apple, WR Travis Rudolph, LB Jeremy Cash, and DT Khyri Thornton are also inative for the Giants.
OL Chad Wheeler will replace Pugh in the lineup at RT, while LB Kelvin Sheppard will fill in for Casillas at WLB.