A day after clinching their first playoff berth in nine years, the Mets put out a makeshift lineup with no full-time starters that outhit the Reds, 13-7.
Michael Conforto's RBI double in the first started the offense's big day.
Dilson Herrera hit a two-run homer and deGrom a two-run single. Kevin Plawecki homered and Juan Lagares had an RBI infield single. Eric Campbell was 3-for-4 and scored three times.
DeGrom (14-8, 2.60), expected to start Game 1 of the NL Division Series next week against the Dodgers, gave up five hits struck out nine and pitched five shutout innings before allowing a run in the sixth.
Eric Goeddel, Sean Gilmartin and Bobby Parnell each pitched a scoreless inning.
The Mets took a one-game lead over the Los Angeles Dodgers in the race for homefield advantage in their likely NLDS matchup. LA's magic number for clinching the NL West was two going into its series finale at Colorado Sunday afternoon
The Mets have a an off day Monday before beginning a three-game series at Philadelphia, which is trying to avoid its first 100-loss season since 1961. Jon Niese will face a starter to be named Tuesday (7:05 p.m., SNY).