Reds pitchers Alfredo Simon and Manny Parra stymied the Mets hitters, allowing just four hits and one earned run. They struck out eight Mets, who have now struck out 61 times in six games.
Eric Young picked up a double as well.
Gonzalez Germen, Kyle Farnsworth and Jose Valverde combined to shut out the Reds in their 3 1/3 innings.
Game Ball: Niese, who looked good in his debut. But, most importantly, he stayed healthy and injury-free.
What's Next: The Mets have Monday off, then travel to Atlanta for their first away game of the season. They play Tuesday night, a 7 p.m. game.