Andrew Brown will instead start in left field.
"It's just not loosening up," Collins said of Granderson's calf. "I told him, 'If I have to lose you one or two games instead of 3-4 weeks, that's fine.'"
Collins said he expects Granderson will be looked at by team doctors sooner than later.
Granderson has reached base safely in 23 straight games, the second-longest current streak in the majors. He has reached safely in a career-best 28 consecutive games.
Granderson is hitting .281 in 135 at bats with seven home runs and 23 RBI with a .389 on-base percentage since May 1.