Pierce is shooting just 36.8% from the field this season, including 26.8% from 3-point territory, both career-lows.
He played just 15 minutes in Friday's loss to the Rockets, going 1-of-6 from the field.
Deron Williams (ankle), Andrei Kirilenko (back) and Jason Terry (knee) will also be out for tonight's game.
As reported yesterday, Williams will be re-evaluated on Monday, while Kirilenko and Terry will be out at least another week.
Brook Lopez, who returned to the court Friday after missing seven games with an ankle injury, was not listed on Saturday's injury report and is expected to start.