Even the best baseball pitchers get put on pitch counts. It's nothing to be ashamed of. Eli has played more games over the past nine years than any other QB in the NFL. He never misses a game or a practice. He is also holding offsite workouts with his receivers in the offseason.
In addition, he's coming off a 20-game season (the downside of making the Super Bowl as a wildcard) and has come firing right out of the gate again this season with an uneven schedule. The Giants also have not had their bye yet this year. ?So, yes, it's a possibility.