The UConn Board of Trustees voted to withdraw the school from the American Athletic Conference and accept an invitation to the Big East Conference on Wednesday.
UConn, which left the Big East in 2013 to join the AAC, will return beginning in the 2020-21 academic year.
Big East presidents approved UConn's invitation on a conference call on Monday.
Each UConn team with the exception of football will play in the Big East. Given the Big East does not have football, the Huskies football team could become independent or move to another conference. Football coach Randy Edsall told the Associated Press he does not know where the football program will end up.
UConn would be the 11th team in the Big East, joining Butler, Creighton, DePaul, Georgetown, Marquette, Providence, St. John's, Seton Hall, Villanova and Xavier.
The school will need to pay the AAC a $10 million withdrawal fee and provide 27 months' notice, based on AAC bylaws, but the two sides are negotiating terms to expedite the move, the AP reports.
The UConn men's basketball team won seven Big East championships while the women's basketball team has 18 Big East titles.
In the AAC, the men's team has one conference title (2016). The Huskies were runners-up in 2014 and 2015, but won the 2014 national championship.
The UConn women's basketball team has never lost an AAC game, regular season or postseason, winning all six conference titles since the league formed.