The Yankees open the 2019 regular season on Thursday, March 28 at Yankee Stadium against the Orioles.
From June 29-30, the Yankees face the Red Sox in London.
- The Yankees face the NL West in Interleague Play, including games at Yankee Stadium against the Padres (May 28-30), Rockies (July 19-21), Diamondbacks (July 30-31), and traveling to play the Dodgers.
- The Subway Series takes place June 10-11 at Yankee Stadium and July 2-3 at Citi Field.
- The Yankees have just two games against the Red Sox over the first two months of the season (April 16-17 at Yankee Stadium).